LIN 7 regulates the filopodia and neurite promoting activity of IRSp 53
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چکیده
LIN7 regulates the filopodia and neurite promoting activity of IRSp53 1 2 3 *Arianna Crespi, *Ilaria Ferrari, Paola Lonati, Andrea Disanza, 1,4 Diego Fornasari, Giorgio 4 Scita, Valeria Padovano, and 1,4,5 Grazia Pietrini. 5 6 1 Department of Medical Biotechnology and Translational Medicine, Università degli Studi di 7 Milano, Milan, Italy 8 2 IFOM, FIRC Institute of Molecular Oncology Foundation at IFOM-IEO Campus, Milan, Italy 9 3 Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Milan, 10 Italy 11 4 CNR-Institute of Neuroscience, Milan, Italy 12 13 14 5 Corresponding author: Grazia PIETRINI, 15 Department of Medical Biotechnology 16 and Translational Medicine 17 Via Vanvitelli 32, 20129 Milano, Italy 18 Phone: +39 02 50317094 19 FAX: +39 02 7490574 20 E-mail: [email protected] 21 22 *These authors equally contributed to this project 23 24 Running title: LIN7 regulation of IRSp53 25 26 © 2012. Published by The Company of Biologists Ltd.
منابع مشابه
LIN7 regulates the filopodium- and neurite-promoting activity of IRSp53.
The insulin receptor substrate protein of 53 kDa (IRSp53) is crucially involved in the formation of filopodia and neurites through mechanisms that have only partially been clarified. We have investigated the role of the small scaffold protein LIN7, which interacts with IRSp53. We found that formation of actin-filled protrusions in neuronal NSC34 cells and neurites in neuroblastoma N2A cells dep...
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Filopodia are dynamic, actin-rich finger-like structures that protrude from the cell membrane and play important roles in cell migration and neurite initiation and outgrowth. The insulin receptor substrate protein of 53 kDa (IRSp53) and the mammalian Diaphanous members of the formin family of proteins (mDia) are two key players in the formation of filopodia and neurites. IRSp53 is an adaptor pr...
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تاریخ انتشار 2012